[1]范向宁,刘 柯,朱久育,等.炎症因子对肥胖大鼠肝脏组织胰岛素信号通路的影响研究[J].中国美容医学,2021,(12):102-104.
　FAN Xiang-ning,LIU Ke,ZHU Jiu-yu,et al.Effects of Inflammatory Factors on Insulin Signal Pathway in Liver Tissue of Obese Rats[J].Medical Aesthetics and Beauty,2021,(12):102-104.
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炎症因子对肥胖大鼠肝脏组织胰岛素信号通路的影响研究()
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2021年12期
页码:
102-104
栏目:
出版日期:
2021-12-10

文章信息/Info

Title:
Effects of Inflammatory Factors on Insulin Signal Pathway in Liver Tissue of Obese Rats
文章编号:
1008-6455（2021）12-0102-03
作者:
范向宁; 刘 柯; 朱久育; 王 磊; 赵清娟; 刘 刚; 黄艳丽
(新乡医学院第三附属医院口腔科 河南 新乡 453000 )
Author(s):
FAN Xiang-ning; LIU Ke; ZHU Jiu-yu; WANG Lei; ZHAO Qing- juan; LIU Gang; HUANG Yan- li
(Department of Stomatology,the Third Affiliated Hospital of Xinxiang Medical College,Xinxiang 453000,Henan,China)
关键词:
炎症; 肥胖; 肝脏; 胰岛素; 胰岛素抵抗; 大鼠
Keywords:
inflammation;  obesity;  liver;  insulin;  insulin resistance;  rat
分类号:
R365.4
文献标志码:
A [
摘要:
目的：探究肥胖对肝脏组织信号通路相关胰岛素抵抗的影响。方法：将10只雄性SD大鼠随机分为两组。对照组用标准饲料喂养，实验组用高脂肪饲料喂养。动物模型以体重和Lee指数为测量指标。采用定量实时聚合酶链反应检测TNF-α、IL-1β、TLR2、TLR4、IRS、PI3K、AKT和GLUT4的mRNA水平。结果：与对照组相比，实验组肝脏组织中TNF-α基因水平显著升高，差异有统计学意义（P＜0.05），同时，IL-1β和TLR4的mRNA水平分别显著降低（P＜0.05）。与对照组相比，实验组肝脏组织中IR、PI3K、AKT和GLUT4基因表达显著降低（P＜0.05）。结论：肥胖抑制肝脏组织胰岛素信号通路的现象与胰岛素抵抗的发生发展有关。
Abstract:
Objective The aim of this study was to study the effect of obesity on IR associated with signal pathways in liver. Methods Ten male SD rats were randomly divided in 2 groups: control group (Con) (fed with standard diet); high-fat diet group (HFD) (fed with high fat diet). The animal model was characterized in terms of body weight (BW) and Lee index. The mRNA levels of tumor necrosis factors ɑ (TNF-ɑ), interleukin-1beta (IL-1 β), Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4), insulin receptor, phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT) and glucose transporter type 4 (GLUT4) were measured by quantitative real-time polymerase chain reaction (RT-PCR). Results Compared with the control group, the TNF- α gene level in the liver tissue of the experimental group was significantly increased, and the difference was statistically significant (P ＜0.05). At the same time, the mRNA levels of IL-1β and TLR4 were significantly decreased (P ＜0.05). Compared with the control group, the expression of IR, PI3K, AKT and GLUT4 genes in the liver tissue of the experimental group was significantly reduced (P＜0.05). Conclusions In obese rats, the insulin signal pathway was inhibited in liver tissue, which is associated with the onset or development of IR

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更新日期/Last Update: 2022-01-18