[1]禚欣欣,顾丽娟,周晓晗.异维A酸联合阿奇霉素及阿达帕林凝胶治疗中重度痤疮的疗效及安全性分析[J].中国美容医学,2024,(3):107-111.
　ZHUO Xinxin,GU Lijuan,ZHOU Xiaohan.Effi cacy and Safety of Isotretinoic Acid Combined with Azithromycin and Adapalin Gel in the Treatment of Moderate and Severe Acne[J].Medical Aesthetics and Beauty,2024,(3):107-111.
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异维A酸联合阿奇霉素及阿达帕林凝胶治疗中重度痤疮的疗效及安全性分析()
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2024年3期
页码:
107-111
栏目:
出版日期:
2024-03-10

文章信息/Info

Title:
Effi cacy and Safety of Isotretinoic Acid Combined with Azithromycin and Adapalin Gel in the Treatment of Moderate and Severe Acne
文章编号:
1008-6455（2024）03-0107-04
作者:
禚欣欣; 顾丽娟; 周晓晗
(淮安市第五人民医院皮肤性病美容科 江苏 淮安 223300 )
Author(s):
ZHUO Xinxin; GU Lijuan; ZHOU Xiaohan
(Department of Dermatology and Aesthetic Surgery,the Fifth People’s Hospital of Huai’an,Huai’an 223300,Jiangsu,China)
关键词:
中重度痤疮; 异维A酸; 阿奇霉素; 皮肤屏障功能
Keywords:
moderate to severe acne;  isotretinoic acid;  azithromycin;  skin barrier function
分类号:
R758.73
文献标志码:
A
摘要:
目的：探讨异维A酸联合阿奇霉素、阿达帕林凝胶治疗中重度痤疮的疗效及安全性。方法：选取2020年1月-2020年12 月笔者医院收治的中重度痤疮患者99例，采用随机数字表法分为对照1组（33例）、对照2组（33例）和观察组（33例）。 对照1组采用局部外涂0.1%阿达帕林凝胶治疗，对照2组采用阿达帕林凝胶联合阿奇霉素治疗。在对照2组的基础上，观察组 联合异维A酸软胶囊治疗，三组均治疗4周。统计三组治疗后的临床疗效、患者满意率及治疗期间不良反应发生情况，比较 三组治疗前后血清性激素水平及皮肤屏障功能。结果：治疗4周后，观察组总有效率及总满意率均高于对照1组、对照2组 （P＜0.05）。治疗后，观察组血清睾酮（Testosterone,T）、孕酮（Progesterone,P）、性激素结合蛋白（Sex hormone binding protein,SHBG）水平均降低，且低于对照1组、对照2组（P＜0.05）；观察组血清雌二醇（Estradiol,E2）、 促卵泡激素（Follicle stimulating hormone,FSH）水平升高，且高于对照1组、对照2组（P＜0.05）；三组角质层含 水量均升高，观察组高于对照1组、对照2组，三组经皮水分丢失量、痤疮综合分级系统（Acne comprehensive grading system,GAGS）积分、红斑评分、色素沉着评分均降低，观察组低于对照1组、对照2组（均P＜0.05）。观察组患者满意率高 于对照组（P＜0.05）。三组不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：异维A酸联合阿奇霉素、阿达帕 林凝胶可有效改善中重度痤疮患者血清性激素水平及皮肤屏障功能，提高患者满意率，临床疗效较好，且不会增加不良反应 的发生。 [
Abstract:
Objective To explore the efficacy and safety of isotretinoic acid combined with azithromycin and adapalin gel in the treatment of moderate and severe acne. Methods 99 patients with moderate and severe acne admitted to the author’s hospital from January 2020 to December 2020 were selected and divided into the control group 1 (33 cases), the control group 2 (33 cases) and the observation group (33 cases) by random number table method. The control group 1 was treated with 0.1% adapalin gel. The control group 2 was treated with 0.1% adapalin gel and azithromycin. On the basis of the control group 2, the observation group was treated with isovitamin A acid soft capsule, all three groups were treated for 4 weeks. The clinical effi cacy, the satisfaction rate and the occurrence of adverse reactions were analyzed in the three groups after 4 weeks of treatment. The level of serum sex hormone and the improvement of skin barrier function in the three groups were compared before and after 4 weeks of treatment. Results After 4 weeks of treatment, the total eff ective rate and total satisfaction rate of the observation group were higher than those of the control group 1, the control group 2 (P＜0.05). After 4 weeks of treatment, the levels of serum testosterone (T), progesterone (P) and sex hormone binding protein (SHBG) in the observation group decreased compared with those before treatment, and which were lower than those in the control group 1, the control group 2 (P＜0.05). The levels of serum estradiol (E2) and follicle stimulating hormone (FSH) in the observation group increased compared with those before treatment, and which were higher than those in the control group 1, the control group 2 (P＜0.05); the cuticle water content of the three groups increased, and the observation group was higher than the control group 1, the control group 2. The percutaneous water loss, scores of acne comprehensive grading system (GAGS), erythema and pigmentation of the three groups decreased, and the observation group was lower than the control group 1, the control group 2 (all P＜0.05). During treatment, there was no signifi cant diff erence in the incidence of total adverse reactions between the observation group and the control group 1, the control group 2 (P＞0.05). Conclusion Isotretinoic acid combined with azithromycin and adapalin gel can eff ectively improve the serum sex hormone levels and skin barrier function of moderate and severe acne patients with moderate and severe acne, improve their satisfaction rate with cosmetic eff ects, and have good clinical effi cacy without increasing the occurrence of adverse reactions.

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更新日期/Last Update: 2024-03-21