[1] 谷晓广,刁云珍,刘永生,等. 自体培养组织工程表皮移植治疗稳定期白癜风初步临床研究[J].中国美容医学,2021,(4):106-109.
　 GU Xiao-guang,DIAO Yun-zhen,LIU Yong-sheng,et al. Preliminary Clinical Study of Autologous Culture Tissue Engineering EpidermalGrafting in the Treatment of Stable Vitiligo[J].Medical Aesthetics and Beauty,2021,(4):106-109.
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2021年4期
页码:
106-109
栏目:
出版日期:
2021-04-10

文章信息/Info

Title:
 Preliminary Clinical Study of Autologous Culture Tissue Engineering Epidermal
Grafting in the Treatment of Stable Vitiligo
文章编号:
1008-6455（2021）04-0106-04
作者:
 谷晓广1; 2; 刁云珍3; 刘永生1; 2; 续言凤1; 2; 高丹旭1; 2
Author(s):
 GU Xiao-guang1; 2; DIAO Yun-zhen3; LIU Yong-sheng1; 2; XU Yan-feng1; 2; GAO Dan-xu1; 2
关键词:
 [关键词]白癜风; 稳定期白癜风; 黑素细胞; 组织工程表皮; 皮肤移植; 自体移植
Keywords:
 Key words: vitiligo;  stable vitiligo;  melanocytes;  tissue engineering epidermis;  skin grafting;  autotransplantation
分类号:
R758.4+1
文献标志码:
A
摘要:
[摘要]目的：探讨自体培养组织工程表皮移植治疗稳定期白癜风的临床疗效。方法：收集皮肤科10～48岁稳定期白癜风患者
42例，切取患者正常皮肤(约2cm×3cm)，通过酶解、消化并培养形成自体培养组织工程表皮。然后将培养的组织工程皮肤
移植到患者白斑处，并进行缝合固定、加压包扎。1周后缝合处拆线、2周后拆除油纱。术后对患者进行随访，并用临床照
片、辅以Wood灯分析色素恢复情况，记录复色情况，评价治疗效果。结果：2014年10月-2019年4月通过自体培养组织工程
表皮移植治疗稳定期白癜风患者42例，随访12个月，结果显示自体培养组织工程表皮移植治疗稳定期白癜风整体有效率为
83.3%，其中头面部有效率最高为94.7%，其次为躯干部皮损为90.9%、四肢的有效率最低为76.2%。头面部治疗有效率明显高
于四肢，差异有统计学意义（P ＜0.05）。结论：自体培养组织工程表皮移植治疗稳定期白癜风效果明显，疗效确切，安全
性高。

Abstract:
Abstract: Objective To investigate the clinical efficacy of autologous culture tissue engineering epidermal grafting in
the treatment of stable vitiligo. Methods A total of 42 patients with stable vitiligo of 10-48 years old were enrolled in the
dermatology department. Cutted the patient’s normal skin (approximately 2cm×3cm), and form autologous culture tissue
engineering epidermis through enzymolysis, digestion and culture. Then the cultured tissue engineered skin is transplanted to
the patient’s leukoplakia, sutured, fixed, and pressure bandaged. after 1 week, the stitches were removed from the suture, and
the oil gauze was removed after 2 weeks. After the operation, the patients were followed up, and the clinical photos were used
to analyze the recovery of the pigment with the aid of the Wood lamp, and the recolor situation was recorded to evaluate the
treatment effect. Results From October 2014 to April 2019, our department treated 42 patients with stable vitiligo through
autologous culture tissue engineering epidermal grafting, and followed up for 12 months. The results showed that the overall
effective rate of vitiligo in the stable period of autologous cultured tissue engineering was 83.3%, with the highest head and face
efficiency of 94.7%, followed by the trunk lesions of 90.9% and the limbs with the lowest efficiency of 76.2%. The effective
rate of head and face was significantly higher than that of limbs, and the difference was statistically significant(P ＜0.05).
Conclusion Autologous cultured tissue engineering epidermal transplantation has obvious effects in the treatment of stable
vitiligo, with definite curative effect and high safety.

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更新日期/Last Update: 2021-05-11