[1] 张兰芳,蒲晓姝. 精准脉冲光联合甲硝唑凝胶治疗玫瑰痤疮疗效观察[J].中国美容医学,2021,(8):76-79.
　 ZHANG Lan-fang,PU Xiao-shu. Cosmetic Effects of Dye Pulse Light Combined with Metronidazole Gel on Rosacea[J].Medical Aesthetics and Beauty,2021,(8):76-79.
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 精准脉冲光联合甲硝唑凝胶治疗玫瑰痤疮疗效观察
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2021年8期
页码:
76-79
栏目:
出版日期:
2021-08-10

文章信息/Info

Title:
 Cosmetic Effects of Dye Pulse Light Combined with Metronidazole Gel on Rosacea
文章编号:
1008-6455(2021)08-0076-03
作者:
 张兰芳; 蒲晓姝
Author(s):
 ZHANG Lan-fang;  PU Xiao-shu
关键词:
 [关键词]玫瑰痤疮; 精准脉冲光; 甲硝唑凝胶; 疗效; 安全性
Keywords:
 Key words:rosacea;  dye pulse light;  metronidazole gel;  curative effect;  safety
分类号:
R758.73+4
文献标志码:
A
摘要:
[摘要]目的：探讨精准脉冲光（DPL）联合甲硝唑凝胶治疗玫瑰痤疮的临床效果。方法：选取2018年4月-2020年4月于笔者医
院就诊的90例Ⅰ型及Ⅱ型玫瑰痤疮患者为研究对象，采用随机数字表法分为对照组和观察组，每组45例。对照组采用甲硝唑
凝胶外用治疗，观察组则采用DPL联合甲硝唑凝胶治疗，两组均于治疗6周后评价临床疗效。比较两组干预前后皮损症状积
分、临床疗效、皮肤病生活质量指数（DLQI）量表评分变化以及不良反应发生情况。结果：治疗后组间比较，观察组红斑、
毛细血管扩张、丘疹、脓疱、瘙痒症状积分及总分均显著低于对照组（P ＜0.05）；观察组和对照组治疗总有效率（95.56%
vs 77.78%）比较，观察组显著高于对照组（P ＜0.05）；两组DLQI评分均较治疗前显著下降（P ＜0.05），组间比较观察组
显著低于对照组（P ＜0.05）；观察组与对照组总不良反应发生率（13.33% vs 8.89%）比较无显著差异（P ＞0.05）。结
论：DPL联合甲硝唑凝胶治疗玫瑰痤疮疗效确切，有助于改善皮损症状，提高患者生活质量水平，且安全性较好。

Abstract:
Abstract: Objective To explore the clinical curative effect of dye pulse light (DPL) combined with metronidazole gel on
rosacea. Methods A total of 90 patients with type I and II rosacea who were treated in the hospital from April 2018 to April
2020 were enrolled. They were divided into control group and observation group by random number table method, 45 cases
in each group. The control group was treated with metronidazole gel, while observation group was treated with DPL and
metronidazole gel. The clinical curative effect of both groups was evaluated after 6 weeks of treatment. The scores of skin lesion
symptoms, clinical curative effect, changes in scores of dermatology life quality index (DLQI) and adverse reactions
before and after intervention were compared between the two groups. Results After treatment, scores of erythema,
telangiectasia, papules, pustules and pruritus, and total score in observation group were significantly lower than those
in control group (P ＜0.05). The total response rate of treatment in observation group was significantly higher than that in
control group (95.56% vs 77.78%,P ＜0.05). After treatment, DLQI scores in both groups were significantly decreased
(P <0.05), which were significantly lower in observation group than control group (P ＜0.05). There was no significant
difference between the two groups in the total incidence of adverse reactions (13.33% vs 8.89%, P ＞0.05). Conclusion
The curative effect of DPL combined with metronidazole gel is significant on rosacea, which is beneficial to improve skin
lesions symptoms and quality of life, with high safety.

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更新日期/Last Update: 2021-09-10