[1]雷 宇,周忠志,兰宏伟,等.象皮生肌膏对糖尿病皮肤溃疡修复的效果及其机理探究[J].中国美容医学,2022,(1):89-92.
　LEI Yu,ZHOU Zhongzhi,LAN Hongwei,et al.Effect of Xiangpi Shengji Ointment on IL-6 and TNF- in Diabetic Skin Ulcer[J].Medical Aesthetics and Beauty,2022,(1):89-92.
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象皮生肌膏对糖尿病皮肤溃疡修复的效果及其机理探究()
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2022年1期
页码:
89-92
栏目:
出版日期:
2022-01-10

文章信息/Info

Title:
Effect of Xiangpi Shengji Ointment on IL-6 and TNF- in Diabetic Skin Ulcer
文章编号:
1008-6455（2022）01-0089-03
作者:
雷 宇 1; 2; 周忠志1; 兰宏伟1; 王婷婷1; 黄新灵1
(1.湖南中医药大学第一附属医院 湖南 长沙 410007 ;2.长沙医学院中医学院 湖南 长沙 410219 )
Author(s):
LEI Yu1; 2; ZHOU Zhongzhi1; LAN Hongwei1; WANG Tingting1; HUANG Xinling1
(1.Hunan University of Chinese Medicine,Changsha 410208,Hunan,China;2.College of Traditional Chinese Medicine,Changsha Medical University,Changsha 410219,Hunan,China)
关键词:
象皮生肌膏; 糖尿病; 皮肤溃疡; 炎症因子; 白细胞介素-6; 肿瘤坏死因子-α
Keywords:
xiangpi shengji ointment;  diabetes;  skin ulcer;  flammatory cytokines;  interleukin-6;  tumor necrosis factor-
分类号:
R587.2
文献标志码:
A
摘要:
目的：研究象皮生肌膏对糖尿病模型大鼠皮肤溃疡的修复作用，初步探究象皮生肌膏的作用机理。方法：选取80只清洁级雄性SD大鼠，随机分成4组，正常组、模型组、贝复新组、象皮生肌膏组。各组分别在治疗7、14d后观察各组皮肤溃疡的修复状况、检测皮肤溃疡组织中IL?6和TNF?α的表达情况。结果：象皮生肌膏组和贝复新组大鼠溃疡创面的修复率较模型组显著增加，差异有统计学意义（P＜0.01），而且象皮生肌膏组修复率较贝复新组更高，差异有统计学意义（P＜0.05）。与正常组相比，模型组内IL-6、TNF-α的含量显著增加（P＜0.01）。与模型组相比，象皮生肌膏组及贝复新组创面组织匀浆中的IL-6、TNF-α的含量显著下降（P＜0.01），且象皮生肌膏组较贝复新组各指标含量下降更明显（P＜0.05）。结论：象皮生肌膏可以加快糖尿病皮肤溃疡的修复，其作用机理可能是调控创面炎性因子IL-6、TNF-α的含量，减少炎性细胞的聚集，加快皮肤溃疡创面的修复。
Abstract:
Objective To observe the effect of Xiangpi Shengji ointment on promoting the healing of diabetic skin ulcer and to study its effect on the inflammatory factors IL-6 and TNF-α in diabetic skin ulcer. Methods Selected 80 clean male SD rats,they were randomly divided into 4 groups:normal group, model group, Berfuxin group and Xiangpi Shengji ointment group. The repair status of skin ulcer and the expression of IL-6 and TNF- α in skin ulcer tissue were observed at 7 and 14 days after intervention. Results The repair rate of ulcer wound in Xiangpi Shengji ointment group and beifuxin group was significantly highe r than that in model group (P＜0.01), and the repair rate in Xiangpi Shengji ointment group was higher than that in beifuxin group (P ＜0.05). Compared with the normal group, IL-6 and TNF in the model group- α The content of was significantly increased (P ＜0.01). Compared with the model group, IL-6 and TNF in the wound tissue homogenate of Xiangpi Shengji ointment group and beifuxin group- α The content of all indexes in Xiangpi Shengji ointment group decreased significantly (P ＜0.01), and the content of all indexes in Xiangpi Shengji ointment group decreased more significantly than that in beifuxin group (P ＜0.05). Conclusion Xiangpi Shengji ointment can accelerate the repair of diabetic skin ulcer. Its mechanism may be to regulate the content of IL-6 and TNF- α, reduce the aggregation of inflammatory cells, and promote the repair of skin ulcer

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更新日期/Last Update: 2022-02-10