[1]王婷婷,马 婷,单 超,等.基质金属蛋白酶3基因多态性与新疆维吾尔族成人慢性牙周炎的相关研究[J].中国美容医学,2023,(6):104-108.
　WANG Tingting,MA Ting,SHAN Chao,et al.Correlation of Matrix Metalloproteinase 3 Polymorphisms with Adults Chronic Periodontitis among Uyghur Adult in Xinjiang[J].Medical Aesthetics and Beauty,2023,(6):104-108.
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基质金属蛋白酶3基因多态性与新疆维吾尔族成人慢性牙周炎的相关研究()
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2023年6期
页码:
104-108
栏目:
出版日期:
2023-06-10

文章信息/Info

Title:
Correlation of Matrix Metalloproteinase 3 Polymorphisms with Adults Chronic Periodontitis among Uyghur Adult in Xinjiang
文章编号:
1008-6455（2023）06-0104-04
作者:
王婷婷1 ; 马 婷1 ; 单 超1 ; 赵 今1; 2
[1.新疆医科大学第一附属医院(附属口腔医院)
Author(s):
WANG Tingting1 ; MA Ting1 ; SHAN Chao1 ; ZHAO Jin1; 2
(1.Department of Dentistry and Endodontics,the First Affi liated Hospital of Xinjiang Medical University,Urumqi 830054,Xinjiang,China; 2.Research Institute of Dentistry of Xinjiang Uygur Autonomous Region,Urumqi 830054,Xinjiang,China)
关键词:
慢性牙周炎; 基因多态性; 基质金属蛋白酶3; 维吾尔族; Meta分析
Keywords:
chronic periodontitis;  polymorphism;  matrix metalloproteinase 3;  Uyghur nationality;  Meta-analysis
分类号:
R780.2
文献标志码:
A
摘要:
目的：探讨基质金属蛋白酶3（Matrix metalloproteinase3,MMP-3）1171 5A/6A基因多态性与新疆维吾尔族成人慢性 牙周炎的相关性。方法：从前期流行调查组获取的墨玉县样本库中随机抽取300例颊黏膜拭子样本（分为健康对照组、轻度 组以及中重度组三组，每组100例），提取DNA并采用限制性片段长度多态性聚合酶链反应检测MMP-3 1171 5A/6A位点的基因 型分布，使用卡方检验、Kruskal-Wallis H检验、Mann-Whitney U检验以及多分类Logistic回归分析MMP-3 1171 5A/6A基因 多态性与牙周炎易感性的相关性。结果：MMP-3 1171 5A/6A的5A6A和6A6A基因型分布在健康对照组与轻度组之间、健康对 照组与中重度组间比较，差异均具有统计学意义（P＜0.05）；5A6A等位基因分布健康对照组与轻度组间的差异具有统 计学意义（P＜0.05）。多分类Logistic回归分析显示，年龄＜35岁、5A/6A基因型及5A等位基因是慢性牙周炎的保护因 素（P＜0.05）。结论：MMP-3 1171 5A/6A基因多态性可能与新疆墨玉县维吾尔族人群慢性牙周炎相关，但仍需要更高质量的 多中心研究进一步证实。
Abstract:
Objective To investigate the correlation between matrix metalloproteinase 3 1171 5A/6A polymorphisms and adult chronic periodontitis among Uyghur adults in Xinjiang. Methods 300 buccal mucosal swab samples were randomly selected from the Moyu County sample base obtained from the previous epidemiological investigation group. DNA was extracted and polymerase chain reaction restricted fragment length polymorphism was used to detect the genotype distribution of MMP 3 1171 5A/6A. Chi-square test, Kruskal-Wallis H test, Mann-Whitney U test and multivariate Logistic regression were used to analyze the correlation between MMP-3 1171 polymorphism and periodontitis susceptibility. Results The case-control study showed that there were signifi cant diff erences in 5A6A and 6A6A genotype distribution between healthy controls and mild periodontitis and between mild periodontitis and moderate to severe periodontitis (P ＜0.05).There was also signifi cant diff erence in allele frequency between healthy controls and mild periodontitis (P＜0.05). Logistic analysis showed that age under 35 years old, 5A/6A genotype and 5A allele were the protective factors of chronic periodontitis (P＜0.05). Conclusion The polymorphism of MMP-3 1171 5A/6A may be related to chronic periodontitis among Uyghur adults in Moyu County of Xinjiang, but higher quality multi-center studies are still needed for further confi rmation.

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更新日期/Last Update: 2023-07-11