[1]孙同祖,张爱华. 削痂时机对深Ⅱ度烧伤局部IL-8释放及创面炎性反应的影响分析[J].中国美容医学,2019,(01):25-27.
　SUN Tong-zu,ZHANG Ai-hua. Effect of Eschar Cutting Time on Local IL-8 Release and Inflammatory Reaction inDeep Second Degree Burns[J].Medical Aesthetics and Beauty,2019,(01):25-27.
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 削痂时机对深Ⅱ度烧伤局部IL-8释放及创面炎性反应的影响分析
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2019年01期
页码:
25-27
栏目:
出版日期:
2019-01-15

文章信息/Info

Title:
 Effect of Eschar Cutting Time on Local IL-8 Release and Inflammatory Reaction in
Deep Second Degree Burns
文章编号:
1008-6455（2019）01-0025-03
作者:
 孙同祖1; 张爱华2
Author(s):
 SUN Tong-zu1; ZHANG Ai-hua2
关键词:
[关键词]削痂; 深Ⅱ度烧伤; 白介素-8; 炎症反应; 时机选择
Keywords:
Key words: eschar ablation;  reaction in deep second degree burns;  interleukin -8;  inflammatory reaction;  timing
分类号:
R622
文献标志码:
A
摘要:
[摘要]目的：探讨削痂时机对深Ⅱ度烧伤局部IL-8释放及创面炎性反应的影响。方法：选取笔者医院2015年10月-2017年10月收
治的深Ⅱ度烧伤患者92例，根据患者的清创时间将其分成A组（n =48）与B组（n=44）。两组患者均行削痂清创术，其中A组在伤
后24h内清创，B组在烧伤24h后清创。比较两组围术期指标，包括手术时间、术中出血量、创面愈合时间、细菌定植量、住院时
间。分别在手术前后不同时段取烧伤局部的创面分泌物，检测两组白介素-8（IL-8）的释放量，并测定创面白介素-1（IL-1）、
白介素6（IL-6）、白介素-10（IL-10）、肿瘤坏死因子-α（TNF-α）水平，用于观察创面炎症反应的变化，并分析两组手术并
发症发生率。结果：A组创面愈合时间、住院时间少于B组，且术后1周的细菌定植量低于B组，差异有统计学意义（P＜0.05）。
两组术后3d、术后1周的创面IL-8释放量较术前、术后1d显著下降，且A组低于B组，差异有统计学意义（P＜0.05）。两组术后1
周创面IL-1、IL-6、TNF-α水平低于术前，IL-10水平高于术前，且A组创面IL-6、TNF-α水平低于B组，IL-10水平高于B组，差
异有统计学意义（P＜0.05）。A组并发症发生率为4.17%，B组为9.09%，组间比较差异无统计学意义（P ＞0.05）。结论：削痂能
下调深Ⅱ度烧伤患者局部IL-8释放量，并减轻创面炎症反应，与烧伤24h后清创相比，在伤后24h内行削痂清创术的效果更好。

Abstract:

Abstract: Objective To investigate the effect of eschar cutting time on local IL-8 release and inflammatory reaction in deep
partial thickness burn. Methods 92 patients with deep second degree burn admitted to our hospital from October 2015 to
October 2017 were selected and divided into group A (n =48) and group B according to their debridement time (n =44). Scab
removal was performed in both groups. Group A underwent debridement within 24 hours after injury. Group B underwent
debridement 24 hours after burn. The indicators of perioperative period were compared between the two groups, including
operation time, intraoperative blood loss, wound healing time, bacterial colonization amount and hospitalization time. The two
groups of interleukin-8(IL-8) release were measured and the levels of interleukin-1(IL-1), interleukin-6(IL-6), interleukin-
10(IL-10), and tumor necrosis factor-α (TNF- α) were measured in the two groups, respectively, to observe the changes of
inflammatory reaction in the wound. The incidence of complications in the two groups was analyzed. Results The wound
healing time and hospitalization time in group A were shorter than those in group B, and the bacterial colonization at 1 week
after operation was lower than that in group B, the differences were statistically significant(P ＜0.05). The amount of IL-8
released from the two groups after 3d and 1 week after operation was significantly lower than that of 1d before and after
operation, and the A group was lower than that of the B group (P ＜0.05). The levels of IL-1, IL-6 and TNF-α in the two groups
were lower than those before operation, and the level of IL-10 was higher than that before operation. Moreover, the levels of
IL-6 and TNF-α in group A were lower than those in group B, and IL-10 level was higher than that in B group. The differences
were statistically significant (P ＜0.05). The incidence of complications in group A was 4.17%, and group B was 9.09%, there
was no significant difference between the two groups (P ＞0.05). Conclusion Eschar ablation can reduce local IL-8 release
and reduce inflammatory reaction in patients with deep second degree burn. Compared with debridement after 24h, the effect of
debridement and debridement is better in 24h after injury.

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更新日期/Last Update: 2019-01-30