[1] 羊乃康,孙 琦. A型肉毒毒素与曲安奈德治疗瘢痕疙瘩的疗效和安全性比较[J].中国美容医学,2020,(5):66-69.
　 YANG Nai-kang,SUN Qi. Comparison of Effi cacy and Safety Between Botulinum Toxin Type A andTriamcinolone Acetonide in the Treatment of Keloid[J].Medical Aesthetics and Beauty,2020,(5):66-69.
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 A型肉毒毒素与曲安奈德治疗瘢痕疙瘩的疗效和安全性比较
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2020年5期
页码:
66-69
栏目:
出版日期:
2020-05-10

文章信息/Info

Title:
 Comparison of Effi cacy and Safety Between Botulinum Toxin Type A and
Triamcinolone Acetonide in the Treatment of Keloid
文章编号:
1008-6455（2020）05-0066-04
作者:
 羊乃康1; 孙 琦2
Author(s):
 YANG Nai-kang1; SUN Qi2
关键词:
 [关键词]A型肉毒毒素; 曲安奈德; 瘢痕疙瘩; 局部注射治疗; 疼痛
Keywords:
 Key words: botulinum toxin type A;  triamcinolone acetonide;  keloid;  local injection;  pain
分类号:
R619+.6
文献标志码:
A
摘要:
[摘要]目的：探究A型肉毒毒素与曲安奈德治疗瘢痕疙瘩的疗效和安全性。方法：收集笔者医院2017年1月-2019年6月收治的
80例瘢痕疙瘩患者的临床资料，依据治疗方法分为观察组（40例）和对照组（40例）。观察组采用A型肉毒毒素局部注射治
疗，对照组采用曲安奈德局部注射治疗。比较两组总有效率、疼痛视觉模拟评分（Visual analogue scale，VAS）、皮损厚
度及不良反应情况。结果：观察组有效率为95.00%显著高于对照组的72.50%，差异有统计学意义（P ＜0.05）。治疗后1个
月、2个月和4个月观察组相同时间点的VAS评分、皮损厚度均显著低于对照组，差异均有统计学意义（P ＜0.05）。观察组不
良反应发生率为10.00%，对照组为27.50%，组间比较差异无统计学意义（P ＞0.05）；治疗4个月后，观察组无复发，对照组
复发6例，复发率为15.00%，组间比较差异有统计学意义（P =0.010）。结论：A型肉毒毒素治疗瘢痕疙瘩的疗效比曲安奈德
更好，能有效降低瘢痕厚度、减轻患者疼痛，复发率低，且不良反应轻微，值得推广。

Abstract:
Abstract: Objective To explore the effi cacy and safety of botulinum toxin type A and triamcinolone acetonide in the treatment
of keloid. Methods The clinical data of 80 patients with keloids admitted to our hospital from January 2017 to June 2019
were collected and divided into the observation group (40 cases) and the control group (40 cases) according to the treatment.
The observation group was treated by local injection of botulinum toxin type A, while the control group was treated by local
injection of triamcinolone acetonide.The total effective rate, pain visual analogue scale (VAS), skin lesion thickness and
adverse reactions were compared between the two groups. Results The effective rate of the observation group was 95.00%,
signifi cantly higher than that of the control group (72.50%), the difference was statistically signifi cant (P ＜0.05). The VAS
score and the thickness of skin lesions in the observation group were signifi cantly lower than those in the control group at 1, 2
and 4 months after treatment (P ＜0.05). The incidence of adverse reactions was 10.00% in the observation group and 27.50%
in the control group, there was no signifi cant difference between groups (P ＞0.05). After 4 months of treatment, there was
no recurrence in the observation group and 6 cases(15.00%) in the control group, and the recurrence rate of the observation
group was signifi cantly lower than that in the control group (P =0.010). Conclusion Botulinum toxin type A is better than
triamcinolone acetonide in the treatment of keloid. It can effectively reduce the thickness of keloid and relieve the pain of
patients with low recurrence rate and mild adverse reactions, which is worthy of promotion.

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更新日期/Last Update: 2020-05-29