[1]熊 瑛,陈 婷,孙文文,等. 非剥脱性点阵激光联合氨甲环酸治疗黄褐斑临床疗效评价[J].中国美容医学,2019,(09):24-26.
　XIONG Ying,CHEN Ting,SUN Wen-wen,et al. Evaluation of Clinical Efficacy on Non-exfoliative Dot Matrix Laser Combined withTranexamic Acid in the Treatment of Patients with Chloasma[J].Medical Aesthetics and Beauty,2019,(09):24-26.
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 非剥脱性点阵激光联合氨甲环酸治疗黄褐斑临床疗效评价
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2019年09期
页码:
24-26
栏目:
出版日期:
2019-09-05

文章信息/Info

Title:
 Evaluation of Clinical Efficacy on Non-exfoliative Dot Matrix Laser Combined with
Tranexamic Acid in the Treatment of Patients with Chloasma
文章编号:
1008-6455（2019）09-0024-03
作者:
熊 瑛; 陈 婷; 孙文文; 吴 波
Author(s):
XIONG Ying; CHEN Ting; SUN Wen-wen; WU Bo
关键词:
[关键词]非剥脱性点阵激光; 氨甲环酸; 黄褐斑; MASI; PGA
Keywords:
Key words: non-exfoliative dot matrix laser;  tranexamic acid;  chloasma;  melasma area and severity index;  physician’s globalassessment
分类号:
R758.4+2
文献标志码:
A
摘要:

[摘要]目的：分析非剥脱性点阵激光联合氨甲环酸治疗黄褐斑的效果。方法：选取笔者医院收治的黄褐斑患者76例，随机
分为对照组和观察组，两组患者均予以氨甲环酸口服治疗，观察组在此基础上加用非剥脱性点阵激光进行治疗。比较两组
患者总有效率，症状积分、黄褐斑面积及严重程度评分（MASI）、整体评价评分（PGA）。结果：观察组患者总有效率为
81.58%，明显高于对照组（60.53%），差异具有统计学意义（P ＜0.05）。两组患者治疗4周后、12周后的症状积分、MASI
评分均降低，且观察组明显低于对照组，差异具有统计学意义（P ＜0.05）。两组患者治疗12周后的PGA评分均高于治疗4周
后，且差异具有统计学意义（P ＜0.05）。治疗4周后、12周后两组患者PGA评分组间比较无统计学差异（P ＞0.05）。结论：
非剥脱性点阵激光联合氨甲环酸治疗黄褐斑可更加有效改善患者临床症状，提高治疗有效率。

Abstract:
Abstract: Objective To analyze the effect on non-exfoliative dot matrix laser combined with tranexamic acid in the
treatment of patients with chloasma. Methods 76 patients with chloasma admitted to our hospital were randomly divided
into the control group and the observation group. Both groups were treated with tranexamic acid orally, and the observation
group was treated with non-exfoliative dot matrix laser. The total effective rate, and the scores of the symptom, melasma
area and severity index (MASI) and physician’s global assessment (PGA) were compared between the two groups. Results
The total effective rate in the observation group was 81.58%, significantly higher than that in the control group (60.53%),
with statistical difference (P ＜0.05). The score of the symptom and MASI in the two groups decreased after 4 weeks and 12
weeks of treatment, but the score in the observation group was significantly lower than that in the control group, with statistical
difference (P ＜0.05). The scores of PGA in the two groups after 12 weeks of treatment were higher than those after 4 weeks of
treatment (P ＜0.05). There was no significant difference in PGA scores between the two groups after 4 weeks and 12 weeks of
treatment (P ＞0.05). Conclusion The treatment of chloasma with non-exfoliative lattice laser combined with carbamaric acid
can improve the clinical symptoms and effective rate of chloasma more effectively.

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更新日期/Last Update: 2019-09-24