[1]王 环.解毒痤疮丸联合异维A酸红霉素凝胶对寻常痤疮中医证候积分及血清SIL-2R、IL-17、Caspase-1水平的影响[J].中国美容医学,2022,(8):120-124.
　WANG Huan.Effect of Acne Detox Pills and Erythromycin Isotretinoin Gel on TCM Syndrome Score and Serum SIL-2R,IL-17 and Caspase-1 Levels with Acne Vulgaris[J].Medical Aesthetics and Beauty,2022,(8):120-124.
点击复制

解毒痤疮丸联合异维A酸红霉素凝胶对寻常痤疮中医证候积分及血清SIL-2R、IL-17、Caspase-1水平的影响()
分享到：

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2022年8期
页码:
120-124
栏目:
出版日期:
2022-08-10

文章信息/Info

Title:
Effect of Acne Detox Pills and Erythromycin Isotretinoin Gel on TCM Syndrome Score and Serum SIL-2R,IL-17 and Caspase-1 Levels with Acne Vulgaris
文章编号:
1008-6455（2022）08-0120-05
作者:
王 环
(辽宁健康产业集团阜新矿总医院皮肤科 辽宁 阜新 123000 )
Author(s):
WANG Huan
(Department of Dermatology,Fuxin Mining General Hospital of Liaoning Health Industry Group,Fuxin 123000,Liaoning,China)
关键词:
寻常痤疮; 解毒痤疮丸; 异维A酸红霉素凝胶; 中医证候积分; SIL-2R; IL-17; Caspase-1
Keywords:
acne vulgaris;  acne detox pills;  isotretinoin erythromycin gel;  TCM syndrome scores;  SIL-2R;  IL-17;  Caspase-1
分类号:
R758.73+3
文献标志码:
B
摘要:
目的：探究解毒痤疮丸联合异维A酸红霉素凝胶对寻常痤疮患者中医证候积分及血清可溶性白细胞介素-2受体（SIL2R）、白细胞介素-17（IL-17）、半胱氨酸蛋白酶-1（Caspase-1）水平的影响。方法：选取2019年1月-2020年6月笔者医院126例寻常痤疮患者，随机分为对照组与观察组，各63例。对照组予以异维A酸红霉素凝胶治疗，观察组予以解毒痤疮丸联合异维A酸红霉素凝胶治疗，均治疗8周。对比两组临床疗效、不良反应发生率及中医证候积分、皮损评分、血清SIL-2R、IL17、Caspase-1水平、外周血T淋巴细胞亚群、经皮水分丢失值、角质层含水量、pH值。结果：治疗8周后观察组临床治疗总有效率（93.65% vs 80.95%）高于对照组（P＜0.05）；治疗4周、8周后，观察组中医证候积分、皮损评分、血清SIL-2R、IL-17、Caspase-1水平均低于对照组（P＜0.05）；治疗4周、8周后，观察组CD3+、CD4+、CD4+/CD8+、角质层含水量高于对照组，CD8+、经皮水分丢失值、pH值低于对照组（P＜0.05）；两组不良反应发生率相比，差异无统计学意义（P＞0.05）。结论：解毒痤疮丸、异维A酸红霉素凝胶治疗寻常痤疮，可显著改善患者症状，调节机体免疫炎性反应，促进皮肤屏障功能恢复，疗效显著，值得临床推广与应用。
Abstract:
Objective To explore the effects of Acne Detox Pills combined with erythromycin isotretinoin gel on TCM syndrome scores and serum soluble interleukin-2 receptor (SIL-2R) and interleukin-17 (IL -17) in patients with acne vulgaris, the influence of Caspase-1 levels. Methods A total of 126 patients with acne vulgaris in author hospital from January 2019 to June 2020 were selected and randomly divided into a control group and an observation group, with 63 cases in each group. The control group was treated with erythromycin isotretinoin gel, and the observation group was treated with Acne Detox Pills combined with erythromycin isotretinoin gel for 8 weeks. Statistically compare the clinical efficacy, incidence of adverse reactions, TCM syndrome scores, skin lesion scores, serum SIL-2R, IL-17, Caspase-1 levels, and peripheral blood T lymphocytes. Subgroups, transdermal water loss value, stratum corneum water content, pH value. Results After 8 weeks of treatment, the total effective rate of clinical treatment in the observation group (93.65% vs 80.95%) was higher than that of the control group (P＜0.05), after 4 weeks and 8 weeks of treatment, the observation group’s TCM syndrome score, skin lesion score, and serum SIL -2R, IL-17, and Caspase-1 levels were lower than those of the control group (P＜0.05), after 4 weeks and 8 weeks of treatment, the CD3+, CD4+, CD4+/CD8+ and cuticle water content of the observation group were higher than those of the control group, and CD8+ The value of transdermal water loss and pH value were lower than those of the control group (P ＜0.05), there was no significant difference in the incidence of adverse reactions between the two groups (P ＞0.05). Conclusion Acne Detox Pills and erythromycin isotretinoin gel in the treatment of acne vulgaris can significantly improve the symptoms of patients, regulate the body’s immune inflammatory response, and promote the recovery of skin barrier function. The curative effect is significant, and it is worthy of clinical promotion and application

相似文献/References:

[1] 谭凌玲,许 芸,王 凯. 四妙汤联合痤疮净粉面膜治疗寻常痤疮疗效分析[J].中国美容医学,2021,(1):142.
　 TAN Ling-ling,XU Yun,WANG Kai. Clinical Efficacy of Simiao Decoction Combined with Acne Powder Mask in theTreatment of Acne Vulgaris[J].Medical Aesthetics and Beauty,2021,(8):142.
[2] 田 秘,洪丽明,汪 伟. 应用姜黄消痤搽剂联合红蓝光治疗寻常痤疮疗效观察[J].中国美容医学,2021,(3):41.
　 TIAN Mi,HONG Li-ming,WANG Wei. Observation on the Effect of Janghuang Xiaocuo Liniment Combined with Red andBlue Light on Acne Vulgaris[J].Medical Aesthetics and Beauty,2021,(8):41.
[3] 刘玉东,李秀丽. 米诺环素结合复方黄柏液涂剂湿敷对寻常痤疮患者症状改善及皮损修复的效果研究[J].中国美容医学,2021,(7):61.
　 LIU Yu-dong,LI Xiu-li. Effects of Minocycline Combined with Compound Huangbai Epithem on Symptoms,Skin Lesions and Acne Scars Score in Acne Patients[J].Medical Aesthetics and Beauty,2021,(8):61.
[4] 邓树广,马 超,李 雪. 毫火针联合常规药物治疗寻常痤疮疗效及安全性分析[J].中国美容医学,2021,(8):107.
　 DENG Shu-guang,MA Chao,LI Xue. Efficacy and Safety Analysis of Fibro-fire Needle Combined with Conventional Drugsin the Treatment of Acne Vulgaris[J].Medical Aesthetics and Beauty,2021,(8):107.
[5] 辜东成,冯菊蕊,李彩霞. 地氯雷他定联合异维A酸在寻常痤疮中的应用[J].中国美容医学,2021,(9):92.
　 GU Dong-cheng,FENG Ju-rui,LI Cai-xia. Application of Desloratadine Combined with Isotretinoin in the Treatmentof Acne Vulgaris[J].Medical Aesthetics and Beauty,2021,(8):92.
[6] 党 辉,李 微,马 瑛. m22强脉冲光联合595nm染料激光治疗寻常痤疮临床观察[J].中国美容医学,2021,(9):107.
　 DANG Hui,LI Wei,MA Ying. Clinical Effects of m22 Intense Pulsed Light Combined with 595nm Dye Laser in theTreatment of Acne Vulgaris[J].Medical Aesthetics and Beauty,2021,(8):107.
[7] 赵文宇,化昊天,胡延申,等. 果酸治疗寻常痤疮疗效的 Meta 分析[J].中国美容医学,2021,(9):111.
　 ZHAO Wen-yu,HUA Hao-tian,HU Yan-shen,et al. The Effect of Safety of Alpha Hydroxy Acid in the Treatment of Acne Vulgaris:A MetaAnalysis[J].Medical Aesthetics and Beauty,2021,(8):111.
[8] 邓 映,杜 宇,杨洪秋,等. 30%超分子水杨酸治疗痤疮炎症后色素沉着疗效观察[J].中国美容医学,2021,(10):78.
　 DENG Ying,DU Yu,YANG Hong-qiu,et al. Effect of 30% Supramolecular Salicylic Acid in Treating Post-inflammatoryHyperpigmentation Secondary to Acne Vulgaris[J].Medical Aesthetics and Beauty,2021,(8):78.
[9] 王 薇,范秀红. 5-氨基酮戊酸光动力联合低剂量异维A酸治疗重度痤疮疗效及安全性分析[J].中国美容医学,2021,(10):97.
　 WANG Wei,FAN Xiu-hong. Effectiveness and Safety Analysis of 5-Aminoketovaleric Acid Combined withIsotretinoin in the Treatment of Severe Acne[J].Medical Aesthetics and Beauty,2021,(8):97.
[10]周 晴,汪 文,是 娴,等.中药凉血清热方联合窄谱强脉冲光治疗痤疮后红斑临床研究?/html>[J].中国美容医学,2021,(11):114.
　ZHOU Qing,WANG Wen,SHI Xian,et al.A Clinical Study on Liangxue Qingre Decoction Combined with Narrow-spectrum Intense Pulsed Light in the Treatment of Erythema after Acne?/html>[J].Medical Aesthetics and Beauty,2021,(8):114.

更新日期/Last Update: 2022-08-25