[1]李 洁,王 倩,赵中华,等.牙周炎正畸患者的龈沟液HMGB1、sICAM-1、IL-33、TSLP水平变化以及与牙周指标的关联性分析[J].中国美容医学,2024,(6):132-136.
　LI Jie,WANG Qian,ZHAO Zhonghua,et al.Changes of HMGB1, sICAM-1, IL-33 and TSLP in Orthodontic Gingival Sulcus Fluid and Correlation with Periodontal Indicators in Periodontitis?/html>[J].Medical Aesthetics and Beauty,2024,(6):132-136.
点击复制

牙周炎正畸患者的龈沟液HMGB1、sICAM-1、IL-33、TSLP水平变化以及与牙周指标的关联性分析()

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2024年6期
页码:
132-136
栏目:
出版日期:
2024-06-10

文章信息/Info

Title:
Changes of HMGB1, sICAM-1, IL-33 and TSLP in Orthodontic Gingival Sulcus Fluid and Correlation with Periodontal Indicators in Periodontitis?/html>
文章编号:
1008-6455（2024）06-0132-04
作者:
李 洁1 ; 王 倩1 ; 赵中华2 ; 郑迎秋3
(1.唐山弘慈医院口腔科 河北 唐山 063000 ;2.唐山职业技术学院口腔系 河北 唐山 063000 ;3.唐山博创口腔医院儿童口腔 科 河北 唐山 063000 )
Author(s):
LI Jie1 ;  WANG Qian1 ;  ZHAO Zhonghua2 ;  ZHENG Yingqiu3
( 1.Department of Stomatology, Tangshan Hongci Hospital, Tangshan 063000, Hebei, China; 2.Department of Stomatology, Tangshan Vocational and Technical College, Tangshan 063000, Hebei, China; 3.Department of Pediatric Stomatology, Tangshan Bochuang Stomatological Hospital, Tangshan 063000, Hebei, China )
关键词:
牙周炎; 正畸; 龈沟液; 高迁移率族蛋白B1; 白细胞介素-33; 菌斑指数; 探诊深度
Keywords:
periodontitis;  orthodontic treatment;  gingival crevicular fl uid;  high mobility group box-1 protein;  interleukin-33;  plaque index;  probing depth
分类号:
R783.5
文献标志码:
A
摘要:
目的：探讨牙周炎正畸患者治疗前后龈沟液高迁移率族蛋白B1（High mobility group box-1 protein，HMGB1）、可 溶性细胞间黏附分子-1（soluble Intercellular adhesion molecule-1，sICAM-1）、白细胞介素-33（Interleukin-33， IL-33 ）、胸腺基质淋巴细胞生成素（Thymic stromal lymphopoietin，TSLP）水平动态变化及与牙周指标的关联性。方 法：选择2019年1月-2021年8月笔者医院就诊的124例牙周炎正畸治疗患者作为研究对象进行回顾性分析，根据患者的治疗 效果分为疗效良好（n=104）与疗效不良（n=20）。对比不同疗效患者的临床资料、牙周指标、龈沟液指标水平，分析牙周 炎正畸患者疗效影响因素及龈沟液指标与牙周指标的关联性，并绘制工作特征曲线（ROC）评价龈沟液指标对患者预后的评 估价值。结果：疗效良好患者治疗后牙周指标[菌斑指数（Plaque index，PLI）、出血指数(Bleeding Index，BI）、探诊 深度（Probing depth，PD）]均低于疗效不良患者，差异有统计学意义（P＜0.05）；疗效良好患者治疗后龈沟液HMGB1、 sICAM-1 、IL-33、TSLP水平均低于疗效不良患者，差异有统计学意义（P＜0.05）；Logistic回归分析可知，治疗后牙周指 标PLI、PD、BI及龈沟液HMGB1、sICAM-1、IL-33、TSLP水平均为牙周炎正畸患者治疗效果不良的影响因素（P＜0.05）； 牙周炎正畸患者龈沟液HMGB1、sICAM-1、IL-33、TSLP水平均与牙周指标PLI、PD、BI呈正相关（P＜0.05）；术后龈沟液 HMGB1 、sICAM-1、IL-33、TSLP水平联合评估牙周炎正畸治疗患者疗效的AUC（0.934）最大，具有较高评估效能。结论：牙 周炎正畸患者治疗前后龈沟液HMGB1、sICAM-1、IL-33、TSLP水平变化与其牙周状态关系密切，联合检测可为临床评估治疗 效果并积极完善治疗方案提供参考。
Abstract:
Objective To investigate the dynamic changes of gingival crevicular fluid high mobility group box-1 protein (HMGB1), soluble intercellular adhesion molecule-1(sICAM-1), interleukin-33 (IL-33), thymic stromal lymphopoietin(TSLP) levels before and after orthodontic treatment of periodontitis and their correlation with periodontal indexes. Methods A total of 124 patients undergoing orthodontic treatment with periodontitis in author’s hospital from January 2019 to August 2021 were selected as the research objects. According to the treatment eff ect, they were divided into good curative eff ect (n=104) and poor curative eff ect (n=20). The clinical data, periodontal index and gingival crevicular fl uid index levels of patients with diff erent curative eff ects were compared, and the factors aff ecting the curative eff ect of orthodontic treatment of periodontitis and the correlation between gingival crevicular fl uid index and periodontal index were analyzed. A receiver operating characteristic curve (ROC) was drawn to evaluate the evaluation value of gingival crevicular fluid indexes for the prognosis of patients. Results The periodontal indexes PLI, PD and BI of patients with good curative eff ect were lower than those with poor curative eff ect after treatment, and the diff erence was statistically signifi cant (P ＜0.05). The levels of gingival crevicular fl uid HMGB1, sICAM-1, IL-33 and TSLP in patients with good curative effect were lower than those with poor curative effect, and the diff erence was statistically signifi cant (P ＜0.05). Logistic regression analysis showed that the periodontal indexes PLI, PD, BI and the levels of gingival crevicular fl uid HMGB1, sICAM-1, IL-33 and TSLP after treatment were all infl uential factors for the poor effi cacy of orthodontic treatment of periodontitis (P ＜0.05). The levels of gingival crevicular fl uid HMGB1, sICAM-1, IL-33, TSLP in patients with periodontitis orthodontic treatment were positively correlated with periodontal indexes PLI, PD, BI (P ＜0.05). The combined level of HMGB1, SICAM-1, IL-33 and TSLP in postoperative gingival crevicular fl uid had the highest AUC of 0.934 in evaluating the effi cacy of orthodontic treatment in patients with periodontitis, indicating a high evaluation effi ciency. Conclusion The changes of gingival crevicular fl uid HMGB1, sICAM-1, IL-33 and TSLP levels before and after orthodontic treatment of periodontitis are closely related to the periodontal status of patients. The combined detection can provide reference for clinical evaluation of the treatment eff ect and actively improve the treatment plan.

相似文献/References:

[1]邹毅军,罗 琴,张靖江,等. 渗透树脂对正畸后牙齿白垩斑的疗效及牙面微硬度和颜色稳定性的影响[J].中国美容医学,2018,(03):87.
　ZOU Yi-jun,LUO Qin,ZHANG Jing-jiang,et al. The Effect of Penetration Resin on the Cretaceous Teeth and Its Effect on the Micro Hardness and Color Stability of the Tooth Surface[J].Medical Aesthetics and Beauty,2018,(6):87.
[2]张晓敏,谭军艳,付兆江. 咬合调整联合正畸治疗牙周病临床观察[J].中国美容医学,2018,(10):114.
　ZHANG Xiao-min,TAN Jun-yan,FU Zhao-jiang. Observation of Effect of Occlusion Adjustment Combined with Orthodontics on Patients with Periodontal[J].Medical Aesthetics and Beauty,2018,(6):114.
[3]霍 丽,高 鹏,冯 雪,等. 活动腭杆在牙性前牙开牙合治疗中的应用[J].中国美容医学,2018,(10):120.
　HUO Li,GAO Peng,FENG Xue,et al. Application of Removable Palatal Bar in the Treatment of Anterior Open Bite[J].Medical Aesthetics and Beauty,2018,(6):120.
[4]张 喆,李大旭,李英杰,等. 骨皮质切开术对大鼠正畸牙牙龈成纤维细胞黏附分子表达水平的影响[J].中国美容医学,2018,(11):141.
　ZHANG Zhe,LI Da-xu,LI Ying-jie,et al. The Effect of Cortical Incision on the Expression of Adhesion Molecules in Rat Gingival Fibroblasts[J].Medical Aesthetics and Beauty,2018,(6):141.
[5]刘梦蕾,刘静雅,韩 晶,等. 渗透树脂对正畸后牙齿白垩斑的疗效及牙面粗糙程度和颜色的影响分析[J].中国美容医学,2019,(06):122.
　LIU Meng-lei,LIU Jing-ya,HAN Jing,et al.Effect of Penetration Resin on the Effect of Dental Plaque and the Roughness andColor of Dental Surface after Orthodontic Treatment[J].Medical Aesthetics and Beauty,2019,(6):122.
[6]冯小东,殷卫红.无托槽隐形矫治对牙周炎正畸患者龈沟液及血清PGE2、sICAM-1、ALP、PAK5的影响[J].中国美容医学,2019,(07):108.
　PGE,sICAM-,ALP,et al.Influences of No Recessive Rectification on Gingival Crevicular Fluid and Serum[J].Medical Aesthetics and Beauty,2019,(6):108.
[7]陈欣媛,唐丽宇,樊 硕,等.比较无托槽隐形矫治器与固定矫治器在正畸中对患者牙周健康的影响[J].中国美容医学,2019,(07):112.
　CHEN Xin-yuan,TANG Li-yu,FAN Shuo,et al.To Compare the Effects of Non-bracket Invisible Orthodontic Appliance and FixedOrthodontic Appliance on Periodontal Health of Patients[J].Medical Aesthetics and Beauty,2019,(6):112.
[8]严玉梅,关晓月,李香娟. 局部应用云南白药治疗牙周炎的Meta分析[J].中国美容医学,2019,(09):122.
　YAN Yu-mei,GUAN Xiao-yue,LI Xiang-juan. Effects of YunNanBaiYao on Treatment of Periodontitis: A Meta Analysis[J].Medical Aesthetics and Beauty,2019,(6):122.
[9]邓溪川,曾翠敏,沈 悦,等. 振动法缓解正畸治疗儿童患者复诊加力后疼痛的有效性分析[J].中国美容医学,2019,(09):129.
　DENG Xi-chuan,ZENG Cui-min,SHEN Yue,et al. Effectiveness of Vibration Method in Relieving Pain after Orthodontic Force for Children[J].Medical Aesthetics and Beauty,2019,(6):129.
[10]于 兰,吕敏敏. 牙周基础治疗联合正畸治疗侵袭性牙周炎疗效评价[J].中国美容医学,2019,(11):103.
　YU Lan,LV Min-min. Evaluation of the Efficacy of Periodontal Orthodontics in the Treatment of Aggressive Periodontitis[J].Medical Aesthetics and Beauty,2019,(6):103.
[11]袁 丽,惠秀丽,刘志峰,等.综合护理干预在儿童口腔正畸中的应用[J].中国美容医学,2022,(3):155.
　YUAN Li,HUI Xiuli,LIU Zhifeng,et al.Application of Comprehensive Nursing Intervention in Children’s Orthodontics[J].Medical Aesthetics and Beauty,2022,(6):155.
[12]刘 媛,王 丁,殷万鑫,等.微种植体支抗对正畸治疗中牙周炎患者血清炎性因子、咬合能力及美学效果的影响[J].中国美容医学,2023,(6):153.
　LIU Yuan,WANG Ding,YIN Wanxin,et al.Infl uence of Micro-implant Anchorage on Serum Infl ammatory Factors, Occlusal Ability and Cosmetic Effect in Patients with Periodontitis During Orthodontic Treatment[J].Medical Aesthetics and Beauty,2023,(6):153.
[13]黄 婧,颜孟雄,童国勇,等.正畸配合牙槽骨再生术治疗成人中重度牙周炎错牙合畸形临床疗效分析[J].中国美容医学,2023,(11):119.[doi:10.15909/j.cnki.cn61-1347/r.005982]
　HUANG Jing,YAN Mengxiong,TONG Guoyong,et al.Effi cacy of Alveolar Bone Regeneration Orthodontic Treatment on Adults with Moderate-to-Severe Periodontitis with Malocclusion[J].Medical Aesthetics and Beauty,2023,(6):119.[doi:10.15909/j.cnki.cn61-1347/r.005982]

更新日期/Last Update: 2024-06-14