[1] 方 慧,陈 滨. 调Q脉冲激光和两种波段强脉冲光治疗面部痤疮后红斑及色素沉着疗效比较[J].中国美容医学,2021,(5):90-94.
　 FANG Hui,CHEN Bin. Curative Effect of Q-switched Pulse Laser and Intensive Pulsed Light on Facial AcneErythema ond Pigmentation[J].Medical Aesthetics and Beauty,2021,(5):90-94.
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 调Q脉冲激光和两种波段强脉冲光治疗面部痤疮后红斑及色素沉着
疗效比较
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2021年5期
页码:
90-94
栏目:
出版日期:
2021-05-10

文章信息/Info

Title:
 Curative Effect of Q-switched Pulse Laser and Intensive Pulsed Light on Facial Acne
Erythema ond Pigmentation
文章编号:
1008-6455(2021)05-0090-04
作者:
 方 慧1; 陈 滨2
Author(s):
 FANG Hui1;  CHEN Bin2
关键词:
 [关键词]寻常痤疮; 红斑; 色素沉着; 调Q脉冲激光; 强脉冲光
Keywords:
 Key words: acne vulgaris;  erythema;  pigmentation;  Q-switched pulse laser;  intensive pulsed light
分类号:
R758.73+3
文献标志码:
A
摘要:
[摘要]目的：探究调Q脉冲激光和两种波段强脉冲光治疗面部痤疮后红斑及色素沉着的临床疗效和安全性。方法：选取2018
年3月-2020年3月笔者医院门诊收治的面部痤疮后红斑及色素沉着患者80例，根据治疗方式的不同分为调Q脉冲激光组（接受
调Q脉冲激光治疗，n =33）和强脉冲光组（接受两种波段的强脉冲光治疗，n =47）。对两种治疗方式的安全性进行评估，比
较两组患者的临床疗效、治疗前后的红斑及色素沉着情况及皮肤生理指标变化水平。结果：调Q脉冲激光组的治疗总有效率
为93.94%，强脉冲光组的治疗总有效率为82.98%，两组治疗总有效率比较无明显差异（P ＞0.05）；治疗后，两组患者的红
斑及色素沉着程度较治疗前明显下降（P＜0.05），且调Q脉冲激光组的色素沉着程度低于强脉冲光组（P＜0.05）；两组患者
的红斑程度无明显差异（P＞0.05）；治疗后，两组患者的皮肤pH值、TEWL均明显下降，角质层含水量明显上升（P ＜0.05），
且调Q脉冲激光组的皮肤pH值低于强脉冲光组，角质层含水量高于强脉冲光组（P ＜0.05），两组患者的经皮水分丢失
（TEWL）水平无明显差异（P ＞0.05）；治疗期间，两组患者出现紧绷感、轻度毛细血管扩张、紫癜等不良反应，未使用任
何药物，症状均于术后1～7d内消失。治疗第2、3次，调Q脉冲激光组患者的VAS评分明显低于强脉冲光组（P ＜0.05），治疗
第1、4次，两组患者的VAS评分无明显差异（P ＞0.05）。结论：调Q脉冲激光与多波段联合强脉冲光在治疗面部痤疮后红斑
及色素沉着方面疗效相当，安全性较高，均可明显改善患者的红斑及色素沉着情况，且无明显不良反应，但调Q脉冲激光在
改善患者红斑程度和皮肤屏障功能方面优于多波段联合强脉冲光。

Abstract:
Abstract:Objective To explore the clinical effects and safety of Q-switched pulse laser and intensive pulsed light in the
treatment of facial acne erythema and pigmentation. Methods A total of 80 patients with facial acne erythema and pigmentation
who were treated at the hospital between March 2018 and March 2020 were divided into Q-switched pulse laser group (33 cases
treated with Q-switched pulsed laser) and intensive pulsed light group (47 cases treated with intensive pulsed light) according
to the treatment method. Safety of the two treatment methods was evaluated. Clinical effects, erythema and pigmentation
before and after treatment, and changes in skin physiological indicators were compared between the two groups. Results
The total response rates of Q-switched pulse laser group and the intensive pulsed light group were 93.94% and 82.98%,
respectively (P ＞0.05). After treatment, erythema and pigmentation in both groups were significantly relieved (P ＜0.05), and
pigmentation in the Q-switched pulse laser group was milder than that in the intensive pulsed light group (P ＜0.05). However,
there was no significant difference in the degree of erythema between the two groups (P ＞0.05). After treatment, skin pH values
and TEWL of both groups decreased significantly, and the water content of stratum corneum increased significantly (P ＜0.05).
Besides, the skin pH value of Q-switched pulse laser group was lower than that of the intensive pulsed light group, and the
water content of stratum corneum was higher than that of the intensive pulsed light group (P ＜0.05). However, there was no
significant difference in transepidermal water loss (TEWL) between the two groups (P ＞0.05). During treatment, there were
adverse reactions such as taut feeling, mild capillary telangiectasia and purpura which disappeared within 1-7 days after surgery
without drug treatment. In the second and third treatments, VAS scores of the Q-switched pulse laser group were significantly
lower than those of the intensive pulsed light group (P ＜0.05). In the first and fourth treatments, there was no significant
difference in VAS score between the two groups (P ＞0.05). Conclusion Q-switched pulse laser and intensive pulsed light are
effective in the treatment of facial acne erythema and pigmentation, with safety. Both can significantly alleviate erythema and
pigmentation without obvious adverse reactions. However,treatment with Q-switched pulse laser is superior to ntensive pulsed
light in relieving erythema and improving skin barrier function.

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更新日期/Last Update: 2021-06-08