[1]徐一凤 综述,王 淳 张梓菁 吴雪岩 柳大可 曾祥吉 金梅花 韩东河 审校.成纤维细胞老化分子机制与皮肤衰老的关系及研究进展[J].中国美容医学,2023,(7):199-202.[doi:10.15909/j.cnki.cn61-1347/r.005800]
　XU Yifeng,WANG Chun,ZHANG Zijing,et al.The Relationship between the Molecular Mechanism of Fibroblast Aging and Skin Aging and Research Progress[J].Medical Aesthetics and Beauty,2023,(7):199-202.[doi:10.15909/j.cnki.cn61-1347/r.005800]
点击复制

成纤维细胞老化分子机制与皮肤衰老的关系及研究进展()
分享到：

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2023年7期
页码:
199-202
栏目:
出版日期:
2023-07-10

文章信息/Info

Title:
The Relationship between the Molecular Mechanism of Fibroblast Aging and Skin Aging and Research Progress
文章编号:
1008-6455（2023）07-0199-03
作者:
徐一凤1 综述; 王 淳1 张梓菁2 吴雪岩1 柳大可1 曾祥吉1 金梅花2 韩东河1 审校
1.大连大学医学院解剖学教研室 辽宁 大连 116622 ;2.大连大学慢性病研究中心 辽宁 大连 116622 )
Author(s):
XU Yifeng1 ; WANG Chun1 ; ZHANG Zijing2 ; WU Xueyan1 ; LIU Dake1 ; ZENG Xiangji1 ; JIN Meihua2 ;  HAN Donghe1
(1.Department of Anatomy,School of Medicine,Dalian University,Dalian 116622,Liaoning,China; 2.Chronic Disease Research Center,Dalian University,Dalian 116622,Liaoning,China)
关键词:
皮肤衰老; 成纤维细胞; 胶原合成; 真皮; 信号通路?/html>
Keywords:
skin aging;  fi broblasts;  collagen synthesis;  dermis;  signaling pathways
分类号:
R339.3+ 8
DOI:
10.15909/j.cnki.cn61-1347/r.005800
文献标志码:
A
摘要:
皮肤衰老是器官老化的最明显表现，其中外部环境和机体内在代谢因素均可加速皮肤老化和退变。研究指出，成纤维 细胞的功能改变是导致皮肤衰老的主要原因，与真皮厚度变薄、皮肤干燥、粗糙、光泽降低及弹性减退密切相关。因此，本 文将聚焦成纤维细胞自身功能学改变、胶原蛋白合成与代谢、成纤维细胞老化分子机制，探讨成纤维细胞老化与皮肤衰老之 间的关系，为研究皮肤衰老提供理论参考。
Abstract:
Skin aging is the most obvious manifestation of organ aging, in which both the external environment and the body’s intrinsic metabolic factors, can accelerate skin aging and degeneration. Studies have pointed out that the functional changes of fi broblasts are the main cause of skin aging, which is closely related to thinning of dermal thickness, dry, rough skin, reduced luster, and hypoelasticity. Therefore, in this paper, we will focus on the functional changes of fi broblasts themselves, collagen synthesis and metabolism, and the molecular mechanism of fi broblast aging, and explore the relationship between fi broblast aging and skin aging, providing a theoretical reference for the study of skin aging.

相似文献/References:

[1]倪 娜,周炳荣,马委委,等. miRNA-769-5p上调对正常人成纤维细胞生物活性的影响[J].中国美容医学,2018,(04):109.
　NI Na,ZHOU Bing-rong,MA Wei-wei,et al. Effect of miRNA-769-5p on Biological Activity of Normal Human Fibroblasts[J].Medical Aesthetics and Beauty,2018,(7):109.
[2]任润健,方 磊,贾传龙,等. PDGF-BB对UVB诱导的光老化成纤维细胞中ROS的影响[J].中国美容医学,2018,(05):109.
　REN Run-jian,FANG Lei,JIA Chuan-long,et al. Effect of PDGF-BB on Reactive Oxygen Species in UVB-induced Skin Fibroblasts[J].Medical Aesthetics and Beauty,2018,(7):109.
[3]朱明宇,李雨珊,王志国,等. 机械牵张力加载时间对诱导正常皮肤成纤维细胞向增生性瘢痕成纤维细胞转化过程的影响研究[J].中国美容医学,2018,(06):55.
　ZHU Ming-yu,LI Yu-shan,WANG Zhi-guo,et al. The Study of the Effect of Mechanical Stretch Loading Time on the Transformation of Normal Skin Fibroblasts to Hypertrophic Scar Fibroblasts[J].Medical Aesthetics and Beauty,2018,(7):55.
[4]王文婷,刘 涛,宋海峰,等. 浅层电子线放射治疗背部瘢痕疙瘩的体外实验与临床疗效观察[J].中国美容医学,2018,(07):87.
　WANG Wen-ting,LIU Tao,SONG Hai-feng,et al. Observation the In Vitro Experiment and Clinical Effectof Postoperative Shallow Electron Beam Radiotherapy in the Treatment of Prothorax Keloid[J].Medical Aesthetics and Beauty,2018,(7):87.
[5]楚菲菲,王大雷,闫 伦,等.阻断Notch信号的角质形成细胞对成纤维细胞增殖及分泌功能的影响研究[J].中国美容医学,2018,(08):73.
　CHU Fei-fei,WANG Da-lei,YAN Lun,et al.Differences of Cell Proliferation and Secretion in Fibroblasts Co-culture with Notch Signaling Occured Keratinocytes[J].Medical Aesthetics and Beauty,2018,(7):73.
[6]徐志山,王洪一,钟黎明,等. 苦参碱对瘢痕疙瘩成纤维细胞生长的抑制作用实验研究[J].中国美容医学,2018,(10):137.
　XU Zhi-shan,WANG Hong-yi,ZHONG Li-ming,et al. Inhibitory Effect of Matrine on the Growth of Keloid Fibroblasts[J].Medical Aesthetics and Beauty,2018,(7):137.
[7]孙 楠,吴 艳,姜 莉. 水母雪莲多糖对中波紫外线诱导的皮肤成纤维细胞凋亡的研究[J].中国美容医学,2019,(03):100.
　SUN Nan,WU Yan,JIANG Li. Study on the Apoptosis of Skin Fibroblasts Induced by UVB in SaussureaMedusa Maxim Polysaccharides[J].Medical Aesthetics and Beauty,2019,(7):100.
[8]孙 楠,吴 艳,姜 莉. 水母雪莲多糖对中波紫外线诱导的皮肤成纤维细胞凋亡的研究[J].中国美容医学,2019,(03):100.
　SUN Nan,WU Yan,JIANG Li. Study on the Apoptosis of Skin Fibroblasts Induced by UVB in SaussureaMedusa Maxim Polysaccharides[J].Medical Aesthetics and Beauty,2019,(7):100.
[9]王 洁,马委委,司晨琛,等. miR-4655-3p在中波紫外线旁观者效应中的作用研究[J].中国美容医学,2019,(04):68.
　WANG Jie,MA Wei-wei,SI Chen-chen,et al. Research on the Role of miR-4655-3p in UVB-radiation Induced Bystander Effects[J].Medical Aesthetics and Beauty,2019,(7):68.
[10]史 敏 李 娜 陈 雷 刘兆旺 魏超鹏综述,封兴华审校. 自噬、miRNA与增生性瘢痕的研究进展[J].中国美容医学,2019,(04):160.
　SHI Min,LI Na,CHEN Lei,et al. Advance in Research on Autophagy, miRNA and Hypertrophic Scar[J].Medical Aesthetics and Beauty,2019,(7):160.
[11]任 捷,马 莉,严淑贤. 杜仲提取液对紫外线照射下真皮成纤维细胞保护作用的研究[J].中国美容医学,2019,(10):99.
　REN Jie,MA Li,YAN Shu-Xian. Protective Effects of Eucommia Ulmoides Oliver Extracts on Ultraviolet Irradiated Human Dermal Fibroblasts[J].Medical Aesthetics and Beauty,2019,(7):99.

更新日期/Last Update: 2023-08-11