[1]项倩彤,崔 伟,张 慧.口服氨甲环酸联合超分子水杨酸换肤治疗黄褐斑的疗效及对血清MDA与E2 的影响[J].中国美容医学,2024,(1):95-98.[doi:10.15909/j.cnki.cn61-1347/r.006088]
　XIANG Qiantong,CUI Wei,ZHANG Hui.Observation of Curative Effect of Tranexamic Acid Combined with Supramolecular Salicylic Acid Peeling in the Treatment of Melasma and Its Infl uences on Serum MDA and E2[J].Medical Aesthetics and Beauty,2024,(1):95-98.[doi:10.15909/j.cnki.cn61-1347/r.006088]
点击复制

口服氨甲环酸联合超分子水杨酸换肤治疗黄褐斑的疗效及对血清MDA与E2 的影响()
分享到：

《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2024年1期
页码:
95-98
栏目:
出版日期:
2024-01-10

文章信息/Info

Title:
Observation of Curative Effect of Tranexamic Acid Combined with Supramolecular Salicylic Acid Peeling in the Treatment of Melasma and Its Infl uences on Serum MDA and E2
文章编号:
1008-6455（2024）01-0095-04
作者:
项倩彤; 崔 伟; 张 慧
[合肥市第二人民医院(安徽医科大学附属合肥医院)
Author(s):
XIANG Qiantong; CUI Wei; ZHANG Hui
[Department of Dermatology,the Second People’s Hospital of Hefei(Hefei Hospital Affi liated to Anhui Medical University),Hefei 230011,Anhui,China]
关键词:
黄褐斑; 氨甲环酸; 超分子水杨酸; 换肤; 丙二醛; 雌二醇
Keywords:
melasma;  tranexamic acid;  supramolecular salicylic acid;  peeling;  malondialdehyde;  estradiol
分类号:
R758.4+ 2
DOI:
10.15909/j.cnki.cn61-1347/r.006088
文献标志码:
A
摘要:
目的：探讨氨甲环酸联合超分子水杨酸换肤治疗黄褐斑临床疗效及对血清丙二醛（MDA），雌二醇（E2）水平的影 响。方法：将2019年12月-2021年12月合肥市第二人民医院皮肤科经治的116例黄褐斑患者随机分为对照组（58例，口服 氨甲环酸片）和观察组（58例，口服氨甲环酸片联合30%超分子水杨酸治疗），两组患者均治疗20周。比较两组患者临床 疗效[医生整体评价（Physician’s global assessment,PGA）、黄褐斑面积和严重指数（Melasma area and severity index,MASI）、皮损评分、经表皮水分流失及皮肤角质层含水量]、主观指标（满意度、睡眠及精神状态）及血清MDA、E2 水平。结果：观察组有效率93.10%高于对照组63.79%（P＜0.05）；两组治疗后MASI、皮损评分、经表皮水分流失及血清 MDA 、E2水平均较治疗前下降，且观察组改善优于对照组（P＜0.05）；两组治疗后角质层含水量均升高，且观察组升高更显 著（P＜0.05）。观察组PGA评分低于对照组（P＜0.05）。观察组治疗后治疗满意度评分、睡眠评分、精神状态评分显著高 于对照组（P＜0.05）。两组治疗期间均未出现不良反应。结论：氨甲环酸联合超分子水杨酸换肤治疗黄褐斑效果显著，并 可改善患者氧化应激反应及雌激素水平。
Abstract:
Objective To investigate the therapeutic effect of tranexamic acid combined with supramolecular salicylic acid peeling on melasma and its infl uences on serum malondialdehyde (MDA) and estradiol (E2) levels. Methods From December 2019 to December 2021, 116 patients with melasma who were admitted to the department of dermatology of hefei second people’s hospital were randomly divided into the control group (58 cases, oral tranexamic acid tablets) and the observation group (58 cases, salicylic acid peeling treatment on the basis of the control group), 20 weeks were treated every group. the clinical efficacy, skin lesions [including physician’s global assessment (PGA), melasma area and severity index (MASI) skin lesion score, transepidermal water loss and stratum corneum water content], subjective indicators (including treatment satisfaction, sleep and mental states), adverse reactions and serum MDA and E2 levels were compared between the two groups. Results The eff ective rate of 93.10% in the observation group was higher than 63.79% in the control group (P ＜0.05); After treatment, MASI, skin lesion score, transepidermal water loss, and serum MDA and E2 levels decreased in both groups compared to before treatment, and the improvement in the observation group was better than that in the control group (P＜0.05); The moisture content of the stratum corneum increased after treatment, and the observation group showed a more signifi cant increase (P ＜0.05). The PGA score of the observation group was lower than that of the control group (P＜0.05). The satisfaction score, sleep score, and mental state score of the observation group after treatment were signifi cantly higher than those of the control group (P ＜0.05). No adverse reactions occurred during the treatment of both groups. Conclusion Tranexamic acid combined with supramolecular salicylic acid peeling has a signifi cant therapeutic eff ect on melasma, and can improve the oxidative stress and estradiol level in patients.

相似文献/References:

[1]李丽娜,郑颖娜,邓丽娜,等. Q开关1 064nm激光联合果酸治疗黄褐斑的临床研究[J].中国美容医学,2018,(03):63.
　LI Li-na,ZHENG Ying-na,DENG Li-na,et al. Q - switched 1 064nm Laser Combined with Acid in the Treatment of Chloasma[J].Medical Aesthetics and Beauty,2018,(1):63.
[2]石莹莹,陈 炜,王露萍,等. 强脉冲光联合氨甲环酸治疗面部黄褐斑MASI评分观察[J].中国美容医学,2018,(05):36.
　SHI Ying-ying,CHEN Wei,WANG Lu-ping,et al. Observation on MASI Score of Intense Pulsed Light IPL Combined with Oral Transamin in the Treatment of Chloasma[J].Medical Aesthetics and Beauty,2018,(1):36.
[3]黄朝卫,解翠林,石 年,等. 女性黄褐斑的临床特点及点阵激光治疗的效果分析[J].中国美容医学,2018,(06):85.
　HUANG Chao-wei,XIE Cui-lin,SHI Nian,et al.The Clinical Characteristics of Female Chloasma and Cosmetic Effect of Dot Matrix Laser Treatment[J].Medical Aesthetics and Beauty,2018,(1):85.
[4]李 卉,胡霜红,王 娟,等. 药物水光注射治疗黄褐斑对患者CK10、SOD及MDA表达水平的影响[J].中国美容医学,2018,(07):75.
　LI Hui,HU Shuang-hong,WANG Juan,et al. Effect on the Expression of CK10, SOD and MDA in Patients with Drug Water Injection in the Treatment of Chloasma[J].Medical Aesthetics and Beauty,2018,(1):75.
[5]杨国峰,张 力.桃红四物合六味地黄汤加减治疗黄褐斑临床疗效评价[J].中国美容医学,2018,(08):133.
　YANG Guo-feng,ZHANG Li. Evaluation of Clinical Efficacy of Modified Taohong Siwu Decoction Combined with six Ingredients Dihuang Decoction in the Treatment of Chloasma[J].Medical Aesthetics and Beauty,2018,(1):133.
[6]陈小燕,刘晓梅,马 瑛,等.优化强脉冲光技术治疗黄褐斑疗效分析[J].中国美容医学,2018,(09):34.
　CHEN Xiao-yan,LIU Xiao-mei,MA Ying,et al.The Efficacy of Optimizedintense Pulsed Light in the Treatment of Chloasma[J].Medical Aesthetics and Beauty,2018,(1):34.
[7]黄朝卫,解翠林,石 年,等.光子嫩肤与调Q激光治疗黄褐斑疗效对比[J].中国美容医学,2018,(10):45.
　HUANG Chao-wei,XIE Cui-lin,SHI Nian,et al. The Contrast Effect of Photorejuvenation and Q Laser Used in Chloasma[J].Medical Aesthetics and Beauty,2018,(1):45.
[8]贾华魁,李琳婕.非剥脱性Lux 1 540nm点阵激光联合氢醌乳膏治疗黄褐斑临床疗效研究[J].中国美容医学,2019,(01):67.
　JIA Hua-kui,LI Lin-jie. Clinical Study on Non-stripping Lux 1 540nm Lattice Laser Combined withHydroquinone Cream in the Treatment of Chloasma[J].Medical Aesthetics and Beauty,2019,(1):67.
[9]张玉洁,刘 瑜,陈阳美,等. 微针导入类人胶原蛋白联合Q开关1 064nm激光治疗黄褐斑疗效观察[J].中国美容医学,2019,(05):8.
　ZHANG Yu-jie,LIU Yu,CHEN Yang-mei,et al. Observation on Clinical Efficacy of Microneedle Importing Human-like Collagen intoSkin Combined with Q-switch 1 064nm Nd:YAG Laser in the Treatment of Melasma[J].Medical Aesthetics and Beauty,2019,(1):8.
[10]张金娥,景 焕,卫静宜,等. 5%氨甲环酸透皮给药治疗黄褐斑疗效分析[J].中国美容医学,2019,(05):11.
　ZHANG Jin-e,JING Huan,WEI Jing-yi,et al. Clinical Efficacy of 5% Tranexamic Acid Transdermal Administration for Treatment of Patients with Melasma[J].Medical Aesthetics and Beauty,2019,(1):11.
[11]孙 慧,吴志波,倪小丽,等. 微针导入氨甲环酸联合Q开关1 064nm激光治疗黄褐斑疗效观察[J].中国美容医学,2018,(05):26.
　SUN Hui,WU Zhi-bo,NI Xiao-li,et al. Clinical Observation of Microneedle Importing Tranexamic Acid into Skin Combinedwith Q Switch 1 064nm Laser for Treating Chloasma[J].Medical Aesthetics and Beauty,2018,(1):26.
[12]韦强梅,江 贺,李冬花,等. 755nm皮秒激光联合口服氨甲环酸治疗黄褐斑疗效观察[J].中国美容医学,2018,(10):34.
　WEI Qiang-mei,JIANG He,LI Dong-hua,et al. Effectiveness of Combination Picosecond 755nm Laser with Tranexamic Acid in the Treament of Melasma[J].Medical Aesthetics and Beauty,2018,(1):34.
[13]段 茜,黄渝瀚,陈玉娟,等. 应用Q开关Nd:YAG激光联合氨甲环酸治疗黄褐斑[J].中国美容医学,2019,(07):24.
　DUAN Xi,HUANG Yu-han,CHEN Yu-juan,et al. Q-switched Nd:YAG Laser Combined with Tranexamic Acid in the Treatment of Chloasma[J].Medical Aesthetics and Beauty,2019,(1):24.
[14]吴一文. 大黄?虫丸联合氨甲环酸与谷胱甘肽治疗黄褐斑[J].中国美容医学,2019,(09):21.
　WU Yi-wen. Chinese Rhubarb Zhechong Pill Combined with Carbamy Lcyclic Acid andGlutathion in the Treatment of Chloasma[J].Medical Aesthetics and Beauty,2019,(1):21.
[15]熊 瑛,陈 婷,孙文文,等. 非剥脱性点阵激光联合氨甲环酸治疗黄褐斑临床疗效评价[J].中国美容医学,2019,(09):24.
　XIONG Ying,CHEN Ting,SUN Wen-wen,et al. Evaluation of Clinical Efficacy on Non-exfoliative Dot Matrix Laser Combined withTranexamic Acid in the Treatment of Patients with Chloasma[J].Medical Aesthetics and Beauty,2019,(1):24.
[16] 赵 婧,许晓爽,鄢 燕. 针刺结合氨甲环酸治疗女性黄褐斑的疗效及其对患者性激素水平的影响[J].中国美容医学,2020,(8):108.
　 ZHAO Jing,XU Xiao-shuang,YAN Yan. Effi cacy of Acupuncture Combined with Tranexamic Acid in the Treatment ofFemale Chloasma and its Effect on Sex Hormone Levels in Patients[J].Medical Aesthetics and Beauty,2020,(1):108.
[17] 李 微,马 瑛,党 辉. 强脉冲光联合氨甲环酸治疗黄褐斑的有效性和安全性分析[J].中国美容医学,2020,(9):33.
　 LI Wei,MA Ying,DANG Hui. Effectiveness and Safety of Intense Pulsed Light Combined with Tranexamic Acid inthe Treatment of Chloasma[J].Medical Aesthetics and Beauty,2020,(1):33.
[18] 罗 倩,严妮娜,郝 瑜. 新型强脉冲光联合氨甲环酸治疗黄褐斑临床研究[J].中国美容医学,2021,(3):27.
　 LUO Qian,YAN Ni-na,HAO Yu. Clinical Study on the Treatment of Melasma with A New Type Intense Pulsed LightCombined with Tranexamic Acid[J].Medical Aesthetics and Beauty,2021,(1):27.
[19]卢改会,李 涛.IPL/激光联合氨甲环酸治疗黄褐斑疗效的系统评价[J].中国美容医学,2022,(1):53.
　LU GaihuiLI Tao.Systematic Evaluation of the Therapeutic Effect of IPL / Laser Combined with Tranexamic Acid on Chloasma[J].Medical Aesthetics and Beauty,2022,(1):53.
[20]毛爱迪,廖 军,尹 锐.Q开关Nd:YAG 1 064 nm激光联合美塑疗法治疗黄褐斑疗效观察[J].中国美容医学,2022,(11):38.
　MAO Aidi,LIAO Jun,YIN Rui.Observation on the Effect of Q-switched Nd:YAG 1 064 nm Laser Combined with Methothrapy on Chloasma[J].Medical Aesthetics and Beauty,2022,(1):38.

更新日期/Last Update: 2024-01-30