[1]喻 路,李 欢.Q开关1 064 nm Nd∶YAG激光联合氨甲环酸超声导入治疗黄褐斑疗效观察[J].中国美容医学,2024,(3):120-123.
　YU Lu,LI Huan.Observation on Therapeutic Effects of Q-switched 1 064 nm NdYAG Laser Combined with Phonophoresis with Tranexamic Acid in the Treatment of Chloasma[J].Medical Aesthetics and Beauty,2024,(3):120-123.
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Q开关1 064 nm Nd∶YAG激光联合氨甲环酸超声导入治疗黄褐斑疗效观察()
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《中国美容医学》[ISSN:1008-6445/CN:61-1347/R]

卷:
期数:
2024年3期
页码:
120-123
栏目:
出版日期:
2024-03-10

文章信息/Info

Title:
Observation on Therapeutic Effects of Q-switched 1 064 nm NdYAG Laser Combined with Phonophoresis with Tranexamic Acid in the Treatment of Chloasma
文章编号:
1008-6455（2024）03-0120-04
作者:
喻 路; 李 欢
(重庆市大足区人民医院皮肤科 重庆 402360 )
Author(s):
YU Lu; LI Huan
(Department of Dermatology,Dazu District People’s Hospital,Chongqing 402360,China)
关键词:
黄褐斑; 氨甲环酸; Q开关Nd∶YAG激光; 超声导入
Keywords:
chloasma;  tranexamic acid;  Q switch NdYAG laser;  phonophoresis
分类号:
R758.4+ 2
文献标志码:
A
摘要:
目的：探究Q开关1 064 nm Nd∶YAG激光联合氨甲环酸超声导入治疗黄褐斑的疗效。方法：选取2022年4月-2022年8月 在大足区人民医院就诊的60例黄褐斑患者为研究对象。按随机分配原则平均将患者分为Nd∶YAG激光组、氨甲环酸组、联合 治疗组，各20例。Nd∶YAG激光组采用Q开关1 064 nm Nd∶YAG激光治疗，氨甲环酸组采用氨甲环酸超声导入治疗，联合治疗 组采用Q开关1 064 nm Nd∶YAG激光治疗联合氨甲环酸超声导入治疗。比较三组临床疗效、不良反应和治疗后6个月复发率。 结果：治疗后，联合治疗组总有效率均高于Nd∶YAG激光组、氨甲环酸组（P＜0.05）；治疗12周后，联合治疗组黄褐斑面积 及严重程度评分（MASI）明显低于Nd∶YAG激光组、氨甲环酸组（P＜0.05）；治疗后，联合治疗组总满意度高于Nd∶YAG激光 组、氨甲环酸组（P＜0.05）；治疗后，三组不良反应发生率（15.00%、15.00%、5.00%）差异无统计学意义（P＞0.05），联 合治疗组半年复发率低于Nd∶YAG激光组及氨甲环酸组（P＜0.05）。结论：Q开关1 064 nm Nd∶YAG激光联合氨甲环酸超声导 入治疗黄褐斑，治疗有效率优于单一治疗方式，安全性良好且不易复发。
Abstract:
Objective This study aimed at investigate the cosmetic results of Q-switched 1 064 nm Nd: YAG laser combined with phonophoresis with tranexamic acid in the treatment of chloasma. Methods A total of 60 patients with chloasma who were treated in the People’s Hospital of Dazu between April 2022 and August 2022 were selected as the research subjects. They were randomly divided into the Nd: YAG laser group, the tranexamic acid group and the combined treatment group with 20 patients in each group. Patients in the three groups were treated with Q-switched 1 064 nm Nd: YAG laser, phonophoresis with tranexamic acid, and Q-switched 1 064 nm Nd: YAG laser combined with phonophoresis with tranexamic acid, respectively. The three groups were compared in terms of clinical effi cacy, adverse reactions and 6-month recurrence rate. Results The total treatment response rate in the combined treatment group were higher when compared with those in the Nd: YAG laser group and the tranexamic acid group (P＜0.05). The Melasma Area and Severity Index (MASI) score of the combined treatment group after 12 weeks of treatment was signifi cantly lower when compared with the scores of the Nd: YAG laser group and the tranexamic acid group (P＜0.05). The total satisfaction rate in the combined treatment group was higher when compared with those in the Nd: YAG laser group and the tranexamic acid group (P＜0.05). The incidence rates of adverse reactions (15.00%, 15.00% and 5.00%) in the three groups showed no statistically signifi cant diff erence (P ＞0.05).The recurrence rate in the combined treatment group was lower than that in the Nd: YAG laser group and tranexamic acid group (P＜0.05). Conclusion Q-switched 1 064 nm Nd: YAG laser combined with phonophoresis with tranexamic acid is superior to single therapy in the treatment of chloasma. In addition, it is safe and the recurrence rate is lower.

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更新日期/Last Update: 2024-03-22